Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats
作者： Amany M. Gad , Ola M. Abd El-Raouf , Bahia M. El-Sayeh , Hala M. Fawzy , Dalaal M. Abdallah
DOI: 10.1002/JBT.21979
关键词:
摘要: Renal toxicity is one of the most severe complications that can occur with cisplatin (CIS) administration in cancer patients. Montelukast (ML) renoprotective outcome contrary to CIS-drawn nephrotoxicity remains obscure. Therefore, adult male Sprague-Dawley rats were orally given ML (10 and 20 mg/kg/day) 5 days before after single CIS (5 mg/kg; i.p.) treatment. returned blood urea nitrogen, as well serum creatinine gamma glutamyl transferase elevated by normal level. The improved kidney function tests corroborated attenuation renal injury at microscopical It also reduced serum/renal nitric oxide hemeoxygenase-1. Meanwhile, hindered raised levels endothelin-1, tumor necrosis factor-α, monocyte chemoattractant protein-1. These effects associated deceased caspase-3 expression In conclusion, guards against CIS-induced via anti-inflammatory antiapoptotic properties.
sci-hub.se 参考文章(45)
Jean Bousquet, Pascal Demoly, Marc Humbert, Montelukast in guidelines and beyond Advances in Therapy. ,vol. 26, pp. 575- 587 ,(2009) , 10.1007/S12325-009-0038-1
Satish L. Deshmane, Sergey Kremlev, Shohreh Amini, Bassel E. Sawaya, Monocyte chemoattractant protein-1 (MCP-1): an overview. Journal of Interferon and Cytokine Research. ,vol. 29, pp. 313- 326 ,(2009) , 10.1089/JIR.2008.0027
F FINSNES, T LYBERG, G CHRISTENSEN, O.H SKJØNSBERG, Leukotriene antagonism reduces the generation of endothelin-1 and interferon-γ and inhibits eosinophilic airway inflammation Respiratory Medicine. ,vol. 96, pp. 901- 906 ,(2002) , 10.1053/RMED.2002.1375
Göksel Şener, Özer Şehirli, Şule Çetinel, Feriha Ercan, Meral Yüksel, Nursal Gedik, Berrak Ç. Yeğen, Amelioration of sepsis-induced hepatic and ileal injury in rats by the leukotriene receptor blocker montelukast Prostaglandins Leukotrienes and Essential Fatty Acids. ,vol. 73, pp. 453- 462 ,(2005) , 10.1016/J.PLEFA.2005.07.008
R. Dong, Q. Wang, X.L. He, Y.K. Chu, J.G. Lu, Q.J. Ma, Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-alpha-induced epithelial-mesenchymal transition of MCF-7 cells. Brazilian Journal of Medical and Biological Research. ,vol. 40, pp. 1071- 1078 ,(2007) , 10.1590/S0100-879X2007000800007
Esra Çikler, Yasemin Ersoy, Şule Çetinel, Feriha Ercan, The leukotriene d4 receptor antagonist, montelukast, inhibits mast cell degranulation in the dermis induced by water avoidance stress. Acta Histochemica. ,vol. 111, pp. 112- 118 ,(2009) , 10.1016/J.ACTHIS.2008.04.006
Melanie Gerstung, Tanja Roth, Hans-Peter Dienes, Christoph Licht, Jochen W.U. Fries, Endothelin-1 Induces NF-κB via Two Independent Pathways in Human Renal Tubular Epithelial Cells American Journal of Nephrology. ,vol. 27, pp. 294- 300 ,(2007) , 10.1159/000101999
Ihab T. Abdel-Raheem, Naglaa F. Khedr, Renoprotective effects of montelukast, a cysteinyl leukotriene receptor antagonist, against methotrexate-induced kidney damage in rats Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 387, pp. 341- 353 ,(2014) , 10.1007/S00210-013-0949-X
Hung-Chun Chen, Jinn-Yuh Guh, Shyi-Jang Shin, Juei-Hsiung Tsai, Yung-Hsiung Lai, Reactive oxygen species enhances endothelin-1 production of diabetic rat glomeruli in vitro and in vivo. Journal of Laboratory and Clinical Medicine. ,vol. 135, pp. 309- 315 ,(2000) , 10.1067/MLC.2000.105616
Eran Neumark, Orit Sagi-Assif, Bruria Shalmon, Adit Ben-Baruch, Isaac P. Witz, Progression of mouse mammary tumors: MCP‐1‐TNFα cross‐regulatory pathway and clonal expression of promalignancy and antimalignancy factors International Journal of Cancer. ,vol. 106, pp. 879- 886 ,(2003) , 10.1002/IJC.11337