The ultrastructural localisation of amine storage sites in the central nervous system with the aid of a specific marker, 5-hydroxydopamine.

摘要: Abstract The ‘false’ neurotransmitter 5-hydroxydopamine has been localised at the ultrastructural level to some nerve terminals in periventricular region of rat hypothalamus and locus coeruleus. Both small large synaptic vesicles these have capacity take up store amine. accumulation is prevented by reserpine pretreatment which indicates a similar uptake storage mechanism for 5-HO-DA as previously described other biogenic amines. number marked this amine both vitro vivo experiments may be related several factors, penetration nerves, retention fixation or it demonstrate true extent specific ‘labelling’ achievable. Since vesicular shown adrenergic peripheral nervous system, our results would then reflect innervation brain, functional difference between dense-cored from those unlabelled terminals.