Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran
作者： Ho Min Kim , Beom Seok Park , Jung-In Kim , Sung Eun Kim , Judong Lee
DOI: 10.1016/J.CELL.2007.08.002
关键词:
摘要: … on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS. … TLR4 in complex with MD-2 and the human TLR4 without bound MD-2. Mouse and human TLR4 …
rcsb.org
core.ac.uk
elsevier.com参考文章(55)
Daniel P Rossignol, Melvyn Lynn, TLR4 antagonists for endotoxemia and beyond. Current opinion in investigational drugs. ,vol. 6, pp. 496- 502 ,(2005)
Ruslan Medzhitov, Paula Preston-Hurlburt, Charles A. Janeway, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity Nature. ,vol. 388, pp. 394- 397 ,(1997) , 10.1038/41131
Xiaolin L. He, J.Fernando Bazan, Gerry McDermott, Jong Bae Park, Kevin Wang, Marc Tessier-Lavigne, Zhigang He, K.Christopher Garcia, Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron. ,vol. 38, pp. 177- 185 ,(2003) , 10.1016/S0896-6273(03)00232-0
Suganya Viriyakosol, Peter S. Tobias, Theo N. Kirkland, Richard L. Kitchens, MD-2 binds to bacterial lipopolysaccharide. Journal of Biological Chemistry. ,vol. 276, pp. 38044- 38051 ,(2001) , 10.1074/JBC.M105228200
Zbyszek Otwinowski, Wladek Minor, Processing of X-ray diffraction data collected in oscillation mode Methods in Enzymology. ,vol. 276, pp. 307- 326 ,(1997) , 10.1016/S0076-6879(97)76066-X
Makiko Kobayashi, Shin-ichiroh Saitoh, Natsuko Tanimura, Koichiro Takahashi, Kiyoshi Kawasaki, Masahiro Nishijima, Yukari Fujimoto, Koichi Fukase, Sachiko Akashi-Takamura, Kensuke Miyake, Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering Journal of Immunology. ,vol. 176, pp. 6211- 6218 ,(2006) , 10.4049/JIMMUNOL.176.10.6211
T.L. Gioannini, A. Teghanemt, DeS. Zhang, E.N. Levis, J.P. Weiss, Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation. Journal of Endotoxin Research. ,vol. 11, pp. 117- 123 ,(2005) , 10.1177/09680519050110020801
Norio Matsushima, Takanori Tanaka, Purevjav Enkhbayar, Tomoko Mikami, Masae Taga, Keiko Yamada, Yoshio Kuroki, Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors BMC Genomics. ,vol. 8, pp. 124- 124 ,(2007) , 10.1186/1471-2164-8-124
Christine Schubert Wright, Qiang Zhao, Fraydoon Rastinejad, Structural Analysis of Lipid Complexes of GM2-Activator Protein Journal of Molecular Biology. ,vol. 331, pp. 951- 964 ,(2003) , 10.1016/S0022-2836(03)00794-0
Osamu Takeuchi, Hideki Sanjo, Katsuaki Hoshino, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira, Tomohiko Ogawa, Taro Kawai, Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. Journal of Immunology. ,vol. 162, pp. 3749- 3752 ,(1999)