Usefulness of predictive tests for cancer treatment

摘要: This review highlights the numerous molecular biology findings in field of lung cancer with potential therapeutic impact both near and distant future. At least six lines research have recently emerged as contributors to changes clinical practice. Abundant pre-clinical data indicate that BRCA1 mRNA expression is a differential modulator chemotherapy sensitivity. Low levels predict cisplatin sensitivity antimicrotubule drug resistance, opposite occurs high levels. Secondly, single nucleotide polymorphisms ERCC1 gene influence survival toxicity cisplatin-based chemotherapy. The main core recent has centered on EGFR mutations copy numbers. For first time, been shown dramatic responses metastatic adenocarcinomas, threefold increase time progression patients receiving tyrosine kinase inhibitors. In contrast, K-ras confer negative effect these patients. Evidence also accumulated crosstalk between estrogen receptor pathways, paving way for trials inhibitors plus aromatase microRNAs control cognate target genes, downregulation Dicer be strong predictor relapse surgically resected non-small-cell Finally, overexpression Wingless-type (Wnt) genes methylation Wnt antagonists like WIF secreted frizzled related proteins documented are believed an important mechanism stem cell maintenance.