Mechanical stress related to brain atrophy in Alzheimer's disease
作者： Marcel Levy Nogueira , Olivier Lafitte , Jean-Marc Steyaert , Hovagim Bakardjian , Bruno Dubois
DOI: 10.1016/J.JALZ.2015.03.005
关键词:
摘要: Abstract Introduction The effects related to endogenous mechanical energy in Alzheimer's disease (AD) pathology have been widely overlooked. With the support of available data from literature and mathematical arguments, we hypothesize that brain atrophy AD could be co-driven by cumulative impact pressure within tissues. Methods Brain volumetric physical normal aging (NA) were extracted literature. Average shrinkage axial deformations evaluated mathematically. Mechanical stress equivalents calculated using a conservation law derived fluid solid mechanics. Results Pressure 5.92 3.43 mm Hg estimated NA, respectively. Discussion increments AD, which impacted marked dampening arterial pulse waves, may point need expand focus on processes underpinning pathologic brain.
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