Personal Exposure to Ultrafine Particles and Oxidative DNA Damage

摘要: Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related risk of cardiovascular and pulmonary disease cancer, even though exposure assessment is difficult. We studied personal in terms number concentrations UFPs the breathing zone, using portable instruments six 18-hr periods 15 healthy nonsmoking subjects. contrasts outdoor pollution were achieved by bicycling traffic for 5 days laboratory 1 day. Oxidative DNA damage was assessed as strand breaks oxidized purines mononuclear cells isolated venous blood morning after measurement. Cumulated cumulated indoor exposures each independent significant predictors level purine oxidation but not breaks. Ambient air particulate matter with an aero-dynamic diameter ≤10 μm (PM10), nitrous oxide, nitrogen dioxide, carbon monoxide, and/or concentration at urban background or busy street monitoring stations a predictor damage, although UFP correlated CO NO2, particularly during traffic. The results indicate that biologic effects occur modest exposure, such occurring traffic, which supports relationship adverse health pollution.