Metabolomics in pharmaceutical research and development: metabolites, mechanisms and pathways.

摘要: In recent years, quantitative metabolomics has played increasingly important roles in pharmaceutical research and development. Metabolic profiling of biofluids tissues can provide a panoramic view abundance changes endogenous metabolites to complement transcriptomics proteomics monitoring cellular responses perturbations such as diseases drug treatments. Precise identification accurate quantification facilitate downstream pathway network analysis using software tools for the discovery clinically accessible minimally invasive biomarkers efficacy toxicity. Metabolite profiles are also indicative biochemical phenotypes, which be used identify novel trait loci genome-wide association studies. This review summarizes experimental computational efforts improve technology well progress towards in-depth integration with other disparate 'omics datasets build mechanistic models form detailed testable hypotheses.