Kidney function estimated from serum creatinine and cystatin C and peripheral arterial disease in NHANES 1999–2002

摘要: Aims Serum cystatin C, a novel marker of kidney function, is reported to be superior serum creatinine as risk factor for atherosclerotic disease, but associations may vary across vascular beds. Methods and results A cross-sectional study chronic disease (CKD) peripheral arterial (PAD) in 3089 adult participants aged 40+ from the 1999–2002 National Health Nutrition Examination Survey (NHANES). Kidney assessed by estimated glomerular filtration rate (eGFR), was determined C using established equations. Peripheral defined an ankle brachial index 90), odds ratio PAD 3.11 (95% confidence interval 1.26–7.64) preclinical CKD (eGFRserum ≥60, eGFRcystatin <76.7) 5.07 (3.01–8.52) ‘confirmed’ <60, <60). Conclusion Chronic strongly independently associated with PAD. Cystatin more potent lower extremity when compared equation currently used clinical practice. Our suggest that have utility combined evaluation individuals who