Inhibition of macrophage-mediated low density lipoprotein oxidation by stimulated rat serosal mast cells
作者： K.A. Lindstedt
DOI: 10.1016/S0021-9258(18)53019-2
关键词:
摘要: Mast cells and macrophages coexist in the human arterial intima where oxidation of low density lipoproteins (LDL) also takes place during atherosclerosis. To investigate whether mast play a role macrophage-mediated LDL, model system was designed which were cocultured incubation medium containing LDL. Stimulation rat serosal to induce exocytosis their cytoplasmic granules found inhibit The inhibitory effect depended on ability cell-derived histamine, released from exocytosed into medium, bind copper ions necessary for propagation macrophage-initiated In addition binding free ions, histamine capable inhibiting LDL propagated by bound apolipoprotein B component particle. results indicate that may prevent cell-mediated imply potentially preventive cell
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