Infusion of increasing doses of endotoxin induces progressive acute lung injury but prevents early pulmonary hypertension in pigs.

作者: Robert Schmidhammer , Esther Wassermann , Peter Germann , Heinz Redl , Roman Ullrich

DOI: 10.1097/01.SHK.0000209529.43367.00

关键词:

摘要: ABSTRACTAdministration of a single bolus endotoxin is model sepsis response in experimental animal studies. Large species, such as pigs and sheep, are more sensitive to administration due an initial excessive pulmonary hypertensive frequently resulting acute r

参考文章(28)
Carl Nathan, Qiao-wen Xie, Nitric oxide synthases: Roles, tolls, and controls Cell. ,vol. 78, pp. 915- 918 ,(1994) , 10.1016/0092-8674(94)90266-6
Thomas Mandrup-Poulsen, Lise D. Wogensen, Michael Jensen, Preben Svensson, Povl Nilsson, Thorkil Emdal, Jens Molvig, Charles A. Dinarello, Jorn Nerup, Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury. Critical Care Medicine. ,vol. 23, pp. 26- 33 ,(1995) , 10.1097/00003246-199501000-00008
Laura C. Green, David A. Wagner, Joseph Glogowski, Paul L. Skipper, John S. Wishnok, Steven R. Tannenbaum, Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Analytical Biochemistry. ,vol. 126, pp. 131- 138 ,(1982) , 10.1016/0003-2697(82)90118-X
Karl Träger, Martin Matejovic, Carl Zülke, Arnim Vlatten, Josef Vogt, Ulrich Wachter, Jürgen Altherr, Alexander Brinkmann, Karl W. Jauch, Michael Georgieff, Peter Radermacher, Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost. Intensive Care Medicine. ,vol. 26, pp. 1531- 1539 ,(2000) , 10.1007/S001340000645
M. Albertini, V. Borromeo, S. Mazzola, B. Ciminaghi, M.G. Clement, Effects of endothelin-1 (ET-1) and thrombin antagonism on cardiovascular and respiratory dysfunctions during endotoxic shock in pig Prostaglandins Leukotrienes and Essential Fatty Acids. ,vol. 67, pp. 445- 451 ,(2002) , 10.1054/PLEF.2002.0455
Daniel L. Traber, Animal models: the sheep. Critical Care Medicine. ,vol. 28, pp. 591- 592 ,(2000) , 10.1097/00003246-200002000-00061
Zsolt Iv??nyi, Bal??zs Hauser, Antje Pittner, Pierre Asfar, Damian Vassilev, Marek Nalos, J??rgen Altherr, Uwe Bernd Br??ckner, Csaba Szab??, Peter Radermacher, Gebhard Fr??ba, Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia. Shock. ,vol. 19, pp. 415- 421 ,(2003) , 10.1097/01.SHK.0000048904.46342.22