Glioblastomas, Astrocytomas: Survival Amelioration Adding Hyperthermia to Conformal Radiotherapy and Temozolomide — Use of Pegylated Doxorubicin and Hyperthermia in the Treatment of a Recurrent Case

摘要: Fifty per cent of primary brain tumours are Glioblastoma (GBM), the rest is constituted by astrocytomas and less aggressive [1,2]. GBM biologically an tumor quickly developing genetic hetereoneity therapeutic resistance [2,3]. No specific markers exist for at moment as reported Kesari [4], but new imaging techniques including diffusion weighted (DWI), perfusion (PWI or MR), aiding in better defining disease development progression. According to World Health Organ‐ ization (WHO), classified into four prognostic grades [4,5]. Grade I two low grade gliomas whereas III IV high gliomas, despite fact that these indicate aggressiveness they have not been reliable predicting response therapy. has outlined other factors such overexpression some growth their receptors relevance [4]. Overexpression Platelet derived factor (PDGF) its indicates a prognosis compared expressing Epidermal Growth Factor (EGFR) [4,6].