Adsorption and inhibition of butyrylcholinesterase by different engineered nanoparticles

摘要: Abstract Butyrylcholinesterase (BChE), an important enzyme present in brain, serum and nervous system, is sensitive to neurotoxin. Engineered nanoparticles (NPs) may enter the mammalian body be toxic. To investigate potential neurotoxicity of different NPs interaction between BChE, three metal (Cu–C, Cu Al), oxides (SiO 2 , TiO Al O 3 ), two carbon nanotubes (MWCNT SWCNT) micro-scaled particles (Cu activated carbon) were used test their adsorption inhibition on human BChE. At 800 mg L −1 BChE by MWCNT highest, 97% 96%, respectively, while showed lowest (6.8%) rates (3.3%). Ions could dissolved all oxide suspensions except NPs. In comparison other ions, 2+ released Cu–C had highest activity reduction, 39.1% 42.6%, respectively. The contribution ions total suspension followed a decreasing sequence (66%) > Cu (46%) > Cu–C (45%) > Al (44%) > SS1[SiO ] (25%) > SP1[SiO (4%), suggesting that partly result from ion dissolution was significantly lower than nano-scaled particles. MWCNT, SWCNT, (HR3) concentration–response relationships. Their median inhibitory concentrations (IC 50 ) 97, 49, 206 1.54 mg L These results indicate these four have potentially as biomarker environment.