Chromium VI - Induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins.
作者： Sakhila K Banu , Jone A Stanley , Kirthiram K Sivakumar , Joe A Arosh , Robert J Taylor
DOI: 10.1016/J.REPROTOX.2016.07.006
关键词:
摘要: Abstract Environmental contamination with hexavalent chromium (CrVI) is a growing problem both in the U.S and developing countries. CrVI heavy-metal endocrine disruptor; women working Cr industries exhibit an increased incidence of premature abortion infertility. The current study was designed to understand mechanism toxicity on placental cell survival/death pathways. Pregnant mothers were treated or without (50 ppm K 2 O 7 ) through drinking water from gestational day (GD) 9.5–14.5, placentas analyzed GD 18.5. Results indicated that apoptosis trophoblasts, vascular endothelium metrial glands yolk sac epithelium caspase-3 p53-dependent labyrinth basal zones caspase-3-independent manner via AIF, ATM-p53-NOXA-PUMA-p27 network. downregulated survival proteins Bcl-2, Bcl-XL XIAP placenta. disrupts histoarchitecture increases death by spatiotemporal modulation apoptotic signaling.
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