Melanoma pigmentation affects melanoma-specific survival and provides a potential target for radiopharmaceutical-based imaging and therapy.

摘要: 8563 Background: The significance of melanoma pigmentation is poorly studied despite being fundamental to melanocyte biology. We examined its pathological and clinical associations in primary melanoma; as a diagnostic target for the novel melanin binding PET tracer [18F]MEL050 advanced melanoma. Methods: Data collected prospectively from 253 patients with cutaneous Standard histological features, BRAF (exon 15) NRAS 2) mutation status, outcome results were correlated against assessed macroscopically by pathologist. Second, 5 stage III/IV planned resection, we performed pilot study [18F]MEL050-PET positive FDG-PET imaging. Results: Pathological data obtained 216 respectively median follow-up 47 months. Lack was present 46 (18.2%) tumors associated increased thickness, nonsuperficial spreading histotype, presence of...