Non-Homologous Animal Models of Affective Disorders: Clinical Relevance of Sensitization and Kindling

摘要: In many ways this chapter would be better titled “uses and abuses of animal models affective disorders.” The previous two chapters have outlined some the systematic criteria for development use various psychiatric disorders, including: similarity behaviors, inducing agents or principles, biochemical physiological correlates, pharmacological responsivity. These been widely accepted, as have, example, confirming that a given chemical is neurotransmitter in central nervous system. Without fulfilling each several criteria, putative candidate cannot considered “proven.” paradigms discussed formal disorder, they do not meet basic requirements an model. particular, there little evidence (1) parallel procedures, (2) behavioral homology to disorder studied, (3) selective response those interventions are successful illness. Nonetheless, these potentially useful other purposes. Specifically, help focus on possible processes clinical situation can conceptualized new ways, perhaps leading series clinical-research formulations, testable hypotheses, even pharmacotherapies.