Inflammatory markers and chronic exposure to fluoxetine, divalproex, and placebo in intermittent explosive disorder

摘要: Intermittent Explosive Disorder (IED) is a disorder of impulsive aggression affecting 4-7% the U.S. population during some period life. In addition to other biological correlates, elevations plasma inflammatory markers have been reported in IED, compared with control, subjects. this study we sought explore if treatment exposure anti-aggressive agents, placebo, would be associated reduction circulating levels markers. Thirty IED subjects, from 12-week, double-blind, randomized, placebo-controlled trial fluoxetine and divalproex, which both pre- post-treatment C-Reactive Protein (CRP), interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10 tumor necrosis factor (TNF)-α were obtained. Efficacy measures included Overt Aggression Scale-Modified (OAS-M) score for Irritability, rate Clinical Global Impression Improvement (CGI-I), Remitters at completion. As neither nor divalproex reduced any aggression. addition, CRP pro- anti-inflammatory cytokines showed no changes condition. Correlations between post- CRP/cytokines substantial (mean r=0.71, r(2)=0.50, p<0.001). Overall, inflammation unaffected by or consistent absence change