Cerebral Toxoplasmosis: Pathogenesis and Host Resistance

摘要: Publisher Summary IFN-γ-mediated immune responses play a central role in resistance against T. gondii the brain. IFN-γ production by multiple types of cells, including T is required for resistance. Microglia one type IFN-γ-producing cells that probably an important controlling parasite. Following acute stage, parasite forms cysts (latent stage) various organs, especially brain, heart, and skeletal muscle, establishing chronic infection. Infection immunocompetent individuals usually unnoticed or benign, self-limiting illness, results latent Immunosuppression chronically infected may result reactivation infection, which initiated disruption cysts, followed proliferation tachyzoites. Such infection presents as toxoplasmic encephalitis (TE). TE has emerged major opportunistic infectious disease nervous system AIDS patients.