Gadodiamide injection: nonionic gadolinium chelate for MR imaging of the brain and spine--phase II-III clinical trial.

摘要: Seventy-three patients with clinically suspected central nervous system abnormalities (44 intracranial, 29 medullospinal) were studied magnetic resonance (MR) imaging before and after administration of nonionic gadodiamide injection. MR showed intracranial lesions in 37 patients. Eight had spinal tumors, 21 disk disease. Structural shown 44 head studies all spine studies. Lesions enhancement was seen 31 28 studies, distinction lesion(s) from associated edema possible 10 one study intrinsic cord tumor. Administration injection provided improved definition lesion borders 19 26 The use the contrast agent changed diagnosis that based on unenhanced images nine 13 Early postcontrast, T1-weighted spin-echo postoperative spines adequate distinguishing epidural scar (enhancing) herniated (nonenhancing). well tolerated, no drug-related adverse events occurred.