New Treatment Options in Neonatal Hyperbilirubinaemia

摘要: Jaundice is one of the most common problems encountered in newborn period. It has been estimated that United States over 60% 4 million newborns born each year develop clinical jaundice with bilirubin levels greater than 5 mg/dL (86 µmol/L) first week life. Bilirubin encephalopathy, known pathologically as kernicterus for yellow staining subthalmic nuclei (kerns), recognized a long time. The degree to which may cause more subtle neurologic abnormalities remains controversial [1]. While commonly newborn, rare occurrence. Factors affect toxicity are complex and incompletely understood. These include; serum albumin concentration available binding sites on bilirubin, integrity blood brain barrier therefore ability enter brain, duration exposure type stage development cells being exposed [2]. relationship between increasing total (TSB) levels, particularly then 20 (344 µmol/L), risk developing infants Rh haemolytic disease (HDN) was observed late 1940s early 1950s [3]. This led an aggressive approach treatment these patients exchange transfusion predominant mode therapy maintain below µmol/L). In 1958 it premature sunlight or blue fluorescent light experienced decrease TSB [4].