The insulin-like growth factor (IGF) axis as an anticancer target in prostate cancer

摘要: Prostate cancer (PCa) is the most common and second leading cause of death in males. In recent years, several new targeting agents have been introduced for treatment advanced stages disease. However, development resistance limits efficacy drugs there a further need to develop additional novel approaches. One investigated targets research insulin-like growth factor (IGF) axis, whose receptors are overexpressed entities including PCa. preclinical studies PCa, IGF axis showed promising anti-tumor effects. Currently available data on clinical do not meet expectations this approach. review we provide summary PCa with monoclonal antibodies tyrosine kinase inhibitors. Moreover, summarize preliminary results from ongoing discuss limitations side effects substances used. We also address role biomarkers setting IGF-binding proteins genetic variants.