Who gets antidotes? choosing the chosen few.

摘要: An understanding of mechanisms, potential benefits and risks antidotes is essential for clinicians who manage poisoned patients. Of the dozens currently available, only a few are regularly used. These include activated charcoal, acetylcysteine, naloxone, sodium bicarbonate, atropine, flumazenil, therapeutic antibodies various vitamins. Even then, most used in minority poisonings. There little randomized trial evidence to support use antidotes. Consequently, decisions about when them often based on mechanistic poisoning expected influence antidote patient's clinical course. For some antidotes, such as atropine insulin, doses employed can be orders magnitude higher than standard dosing. Importantly, patients reach hospital recover with supportive care alone. In low risk patients, routine even charcoal unwarranted. more serious poisonings, regarding generally guided by risk/benefit assessment quality evidence.