DTPACE: An Effective, Novel Combination Chemotherapy With Thalidomide for Previously Treated Patients With Myeloma
作者： Choon-Kee Lee , Bart Barlogie , Nikhil Munshi , Maurizio Zangari , Athanasios Fassas
关键词:
摘要: Purpose: To improve outcome in previously treated patients (at least two cycles of standard therapy) with multiple myeloma, thalidomide was combined cytotoxic chemotherapy as induction therapy. Patients and Methods: The regimen consisted 4-days oral dexamethasone, daily thalidomide, 4 days continuous-infusion cisplatin, doxorubicin, cyclophosphamide, etoposide (DTPACE). Response to DTPACE for evaluated 236 patients. Before being DTPACE, 148 (63%) had shown progressive disease while receiving chemotherapy, 55 (23%) chromosome 13 abnormalities. Results: partial remission rate (PR) after 32%, 16% attaining a complete (CR) or near-CR (nCR; defined only immunofixation electrophoresis–positive). high lactate dehydrogenase (LDH; n = 98) showed better response than those normal LDH (n 138): PR better, 43% v 27% (P .01); CR + nCR, 25% 11% ...
jco.org参考文章(25)
B. Barlogie, S. Jagannath, K.R. Desikan, S. Mattox, D. Vesole, D. Siegel, G. Tricot, N. Munshi, A. Fassas, S. Singhal, J. Mehta, E. Anaissie, D. Dhodapkar, S. Naucke, J. Cromer, J. Sawyer, J. Epstein, D. Spoon, D. Ayers, B. Cheson, J. Crowley, Total Therapy With Tandem Transplants for Newly Diagnosed Multiple Myeloma Blood. ,vol. 93, pp. 55- 65 ,(1999) , 10.1182/BLOOD.V93.1.55
Jean-Paul Fermand, Philippe Ravaud, Sylvie Chevret, Marine Divine, Véronique Leblond, Coralie Belanger, Margaret Macro, Edouard Pertuiset, François Dreyfus, Xavier Mariette, Catherine Boccacio, Jean-Claude Brouet, High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue treatment? Results of a multicenter sequential randomized clinical trial. Blood. ,vol. 92, pp. 3131- 3136 ,(1998) , 10.1182/BLOOD.V92.9.3131
B Barlogie, R Hall, A Zander, K Dicke, R Alexanian, High-dose melphalan with autologous bone marrow transplantation for multiple myeloma. Blood. ,vol. 67, pp. 1298- 1301 ,(1986) , 10.1182/BLOOD.V67.5.1298.1298
D Cunningham, L Paz-Ares, S Milan, R Powles, M Nicolson, T Hickish, P Selby, J Treleavan, C Viner, J Malpas, High-dose melphalan and autologous bone marrow transplantation as consolidation in previously untreated myeloma. Journal of Clinical Oncology. ,vol. 12, pp. 759- 763 ,(1994) , 10.1200/JCO.1994.12.4.759
Said M. Baidas, Eric P. Winer, Gini F. Fleming, Lyndsay Harris, James M. Pluda, Jeanette G. Crawford, Hideko Yamauchi, Claudine Isaacs, John Hanfelt, Mariella Tefft, David Flockhart, Michael D. Johnson, Michael J. Hawkins, Marc E. Lippman, Daniel F. Hayes, Phase II Evaluation of Thalidomide in Patients With Metastatic Breast Cancer Journal of Clinical Oncology. ,vol. 18, pp. 2710- 2717 ,(2000) , 10.1200/JCO.2000.18.14.2710
David H. Vesole, John J. Crowley, Rose Catchatourian, Patrick J. Stiff, David B. Johnson, Jeana Cromer, Sydney E. Salmon, Bart Barlogie, High-Dose Melphalan With Autotransplantation for Refractory Multiple Myeloma: Results of a Southwest Oncology Group Phase II Trial Journal of Clinical Oncology. ,vol. 17, pp. 2173- 2173 ,(1999) , 10.1200/JCO.1999.17.7.2173
Peter J. Selby, Timothy J. McElwain, Ann C. Nandi, Timothy J. Perren, Raymond L. Powles, Colin R. Tillyer, Richard J. Osborne, Maurice L. Slevin, James S. Malpas, Multiple myeloma treated with high dose intravenous melphalan British Journal of Haematology. ,vol. 66, pp. 55- 62 ,(1987) , 10.1111/J.1365-2141.1987.TB06890.X
Bart Barlogie, Lon Smith, Raymond Alexanian, Effective Treatment of Advanced Multiple Myeloma Refractory to Alkylating Agents New England Journal of Medicine. ,vol. 310, pp. 1353- 1356 ,(1984) , 10.1056/NEJM198405243102104
Ted A. Gooley, Wendy Leisenring, John Crowley, Barry E. Storer, Estimation of failure probabilities in the presence of competing risks: new representations of old estimators Statistics in Medicine. ,vol. 18, pp. 695- 706 ,(1999) , 10.1002/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O
NOOPUR RAJE, RAY POWLES, SAMAR KULKARNI, SARAH MILAN, GARY MIDDLETON, SEEMA SINGHAL, JAYESH MEHTA, BARBARA MILLAR, CHRISTINE VINER, JULIAN RAYMOND, JENNIFER TRELEAVEN, DAVID CUNNINGHAM, MARTIN GORE, A comparison of vincristine and doxorubicin infusional chemotherapy with methylprednisolone (VAMP) with the addition of weekly cyclophosphamide (C‐VAMP) as induction treatment followed by autografting in previously untreated myeloma British Journal of Haematology. ,vol. 97, pp. 153- 160 ,(1997) , 10.1046/J.1365-2141.1997.D01-2122.X