Thyroid fine-needle aspiration with atypia of undetermined significance

摘要: BACKGROUND: Atypia of undetermined significance is a controversial category in thyroid fine-needle aspiration (FNA), not only for its questioned clinical utility, but also very existence as an expression uncertainty. The current study was performed to investigate the potential impact eliminating this on sensitivity and specificity detecting neoplasms by FNA. METHODS: Forty cases originally diagnosed atypia with histologic follow-up were selected present study. These reinterpreted blindly 2 experienced reviewers, who eliminated diagnostic possibility reclassified these either benign, follicular neoplasm, suspicious malignancy, or malignant. Twenty-six randomly reevaluated 6 months later intraobserver variation. RESULTS: After category, papillary carcinoma (PTC) reduced from 100% 27% (P = .04). In those that 37% had PTC. neoplasm 38% histologically proven be benign lesions. Unanimous interobserver agreement observed 60% cases. CONCLUSIONS: Eliminating diagnosis substantially decreases FNAs increases both false-positive false-negative rates. addition, it variability. Therefore, should eliminated; we advocate minimizing use. Cancer (Cancer Cytopathol) 2009. © 2009 American Society.