Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.

摘要: Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells. Cytotoxic CD1-restricted lymphocytes recognizing mycobacterial were found in tuberculosis patients. However, thanks a complex interplay between mycobacteria system, M. possesses successful tactic based, at least part, downregulation evade CD1-dependent immunity. On the ground these findings, it is reasonable hypothesize that modulation protein expression by chemical, biological, infectious agents could influence host's immune reactivity against tuberculosis-associated lipids, possibly affecting antitubercular resistance. This scenario prompted us perform detailed analysis literature concerning effect external order obtain valuable information possible strategies be adopted for driving properly functions human pathology particular, tuberculosis.