Effect of medication on microvascular vasodilatation in patients with systemic lupus erythematosus.

摘要: The aim of this study was to investigate the microvascular responses in skin, local heat, iontophoretically administered acetylcholine and sodium nitroprusside relation cardiovascular damage patients with systemic lupus erythematosus (SLE) matched controls. We also wanted examine if ongoing medication SLE influenced vascular response. investigated 30 women compared them 20 age sex-matched cutaneous blood flow response heat (+44 degrees C), endothelium-dependent (acetylcholine), as well independent (sodium nitroprusside) vasodilatation, measured by laser Doppler flowmetry. Clinical data were retrieved from clinical database patient records. reactivity did not differ between a group controls nor it correlate [assessed Systemic Lupus International Collaborating Clinics/American College Rheumatology Damage Index (SLICC/ACR-DI)]. However, on antimalarial drugs (hydroxychloroquine n = 8 chloroquine diphosphate 3) responded more strongly (endothelium-independent vasodilatation) those without (p 5 mg daily) associated reduced < 0.05). Smokers general tended have lower 0.064). Smoking versus non-smoking had significantly 0.01). Medication drugs-enhanced endothelium-independent while glucocorticoid use reduction warfarin-treatment enhancement vasodilatation. Therefore, despite there is no difference other factors such smoking may affect vasodilatation patients. (Less)