Pluripotent Stem Cell Banks

摘要: Embryonic stem cells (ESCs) are pluripotent that can be obtained from the inner cell mass (ICM) of blastocyst-stage pre-implantation embryos. The first lines human ESC (hESC) were derived by Thomson et al. in 1998. These indefinitely cultured vitro and differentiated into different types. constitute an excellent source for study genetics gene expression patterns as a tool to understand events take place during embryo development. also useful drug screening disease modelling. In 2006, Takahashi Yamanaka introduced technology induced reprogramming pluripotency mouse later cells. (iPSCs) generated through somatic back embryonic-like state. process is addition exogenous factors. Human iPSC (hiPSC) avoids destruction embryos ethical debate involved. Moreover, patient-specific this providing unprecedented opportunities, not only regenerative medicine but basic research models, discovery toxicology. emerging demands applications require establishment cooperation centralized banks at translational even global scale. This will ensure availability high-quality hPSC using standardized state-of-the-art methods strategies deal with heterogeneous regulatory, legal landscape. Furthermore, essential distribution among centres, promoting scientific collaboration facilitating widespread use clinical applications.