Changes in Cortically Related Intermuscular Coherence Accompanying Improvements in Locomotor Skills in Incomplete Spinal Cord Injury

摘要: In human spinal cord injury, the neuronal mechanisms mediating improvement of locomotor function in response to intensive treadmill training are not well understood. this study, we examined if such recovery is mediated, part, by increases residual corticospinal drive muscles leg during walking. To do this, measured coherence electromyogram (EMG) activity between two antagonist (intermuscular coherence), specifically at frequencies 24 and 40 Hz, which thought indicate common from inputs. 12 subjects with incomplete intermuscular was hamstrings vastus lateralis EMG that activated walking on a motorized treadmill. Before training, appreciable 24-40 Hz frequency band only present moderate volitional motor strength their (n = 8 subjects) compared little or no muscle 4 subjects), reconfirming likely mediated supraspinal After occurred eight who also exhibited improvements as assessed 21 point WISCI II scale (termed responders). contrast, development did occur four absent weak strength. These improve ability reflected unchanging scores nonresponders). Lower-frequency (5-18 Hz), contain inputs, change either group. subset were previously transcranial magnetic stimulation (TMS) before after 5 responders 3 nonresponders), there significant positive relationship evoked responses TMS primary cortex. Taken together, higher-frequency voluntary its parallel relation changes TMS-evoked provides further evidence