PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells.

作者: P. Loke , J. P. Allison

DOI: 10.1073/PNAS.0931259100

关键词:

摘要: PD-L1 and PD-L2 are ligands for PD-1, a costimulatory molecule that plays an inhibitory role in regulating T cell activation in the periphery. We find that PD-L1 is highly expressed on …

参考文章(31)
Zeina H. Jaffar, Stephen T. Holgate, Kong-Sang Wan, Kevan Roberts, Shiour-Ching Lee, Regulation of pulmonary T cell responses to inhaled antigen: role in Th1- and Th2-mediated inflammation. Journal of Immunology. ,vol. 162, pp. 6867- 6879 ,(1999)
Y. Ishida, Y. Agata, K. Shibahara, T. Honjo, Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. The EMBO Journal. ,vol. 11, pp. 3887- 3895 ,(1992) , 10.1002/J.1460-2075.1992.TB05481.X
Haidong Dong, Gefeng Zhu, Koji Tamada, Lieping Chen, B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion Nature Medicine. ,vol. 5, pp. 1365- 1369 ,(1999) , 10.1038/70932
Robert A. Seder, Adrian V. S. Hill, Vaccines against intracellular infections requiring cellular immunity. Nature. ,vol. 406, pp. 793- 798 ,(2000) , 10.1038/35021239
Thomas A Hamilton, Yoshihiro Ohmori, Julie Tebo, Regulation of chemokine expression by antiinflammatory cytokines. Immunologic Research. ,vol. 25, pp. 229- 245 ,(2002) , 10.1385/IR:25:3:229
Linda Liang, William C Sha, The right place at the right time: novel B7 family members regulate effector T cell responses Current Opinion in Immunology. ,vol. 14, pp. 384- 390 ,(2002) , 10.1016/S0952-7915(02)00342-4
Xiaoyu Hu, Carmen Herrero, Wai-Ping Li, Taras T. Antoniv, Erik Falck-Pedersen, Alisa E. Koch, James M. Woods, G. Kenneth Haines, Lionel B. Ivashkiv, Sensitization of IFN-γ Jak-STAT signaling during macrophage activation Nature Immunology. ,vol. 3, pp. 859- 866 ,(2002) , 10.1038/NI828
Sergij Goerdt, Constantin E Orfanos, Other Functions, Other Genes Immunity. ,vol. 10, pp. 137- 142 ,(1999) , 10.1016/S1074-7613(00)80014-X
P'ng Loke, Andrew S. MacDonald, Amy Robb, Rick M. Maizels, Judith E. Allen, Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell‐to‐cell contact European Journal of Immunology. ,vol. 30, pp. 2669- 2678 ,(2000) , 10.1002/1521-4141(200009)30:9<2669::AID-IMMU2669>3.0.CO;2-1
Haidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Celis, Lieping Chen, Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion Nature Medicine. ,vol. 8, pp. 793- 800 ,(2002) , 10.1038/NM730