Volume overload and cardiorenal syndromes.

摘要: To include the vast array of interrelated derangements and to stress bidirectional nature heart-kidney interactions, classification cardiorenal syndrome today includes 5 subtypes whose terminology reflects their primary secondary pathology, time frame, presence concomitant cardiac renal dysfunction. Cardiorenal syndromes (CRSs) are pathophysiologic disorders heart kidneys whereby acute or chronic dysfunction one organ may induce other. Type 1 CRS an abrupt worsening function leading kidney injury. 2 describes abnormalities in causing progressive disease. 3 consists disorder. 4 a state disease contributing decreased function, hypertrophy, and/or increased risk adverse cardiovascular events. systemic condition (eg, sepsis) simultaneously both Biomarkers can help characterize as well suggest timing treatment initiation its likely effectiveness. The identification patients mechanisms underlying each subtype, including fluid overload or, general, altered conditions status, physicians understand clinical derangements, provide rationale for management strategies, allow design future trials with more accurate selection stratification population under investigation.