EGFR- and HER2-Binding Affibody Molecules : Cellular studies of monomeric, dimeric and bispecific ligands

作者: Lina Ekerljung

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摘要: Abnormal expression and signaling of the ErbB receptors is associated with development progression several forms cancer. In this thesis, new ErbB-targeting affibody molecules are eval ...

参考文章(132)
M. J. Wieduwilt, M. M. Moasser, The epidermal growth factor receptor family: Biology driving targeted therapeutics Cellular and Molecular Life Sciences. ,vol. 65, pp. 1566- 1584 ,(2008) , 10.1007/S00018-008-7440-8
Maria Sundvall, Kristiina Iljin, Sami Kilpinen, Henri Sara, Olli-Pekka Kallioniemi, Klaus Elenius, Role of ErbB4 in breast cancer Journal of Mammary Gland Biology and Neoplasia. ,vol. 13, pp. 259- 268 ,(2008) , 10.1007/S10911-008-9079-3
C. King, M. Kraus, S. Aaronson, Amplification of a novel v-erbB-related gene in a human mammary carcinoma Science. ,vol. 229, pp. 974- 976 ,(1985) , 10.1126/SCIENCE.2992089
Joachim Feldwisch, Vladimir Tolmachev, Christofer Lendel, Nina Herne, Anna Sjöberg, Barbro Larsson, Daniel Rosik, Eva Lindqvist, Gunilla Fant, Ingmarie Höidén-Guthenberg, Joakim Galli, Per Jonasson, Lars Abrahmsén, Design of an optimized scaffold for affibody molecules. Journal of Molecular Biology. ,vol. 398, pp. 232- 247 ,(2010) , 10.1016/J.JMB.2010.03.002
F. Ozcan, P. Klein, M. A. Lemmon, I. Lax, J. Schlessinger, On the nature of low- and high-affinity EGF receptors on living cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 5735- 5740 ,(2006) , 10.1073/PNAS.0601469103
Claire Marie-Elisabeth Sauvageot, Jessica Leigh Weatherbee, Santosh Kesari, Susan Elizabeth Winters, Jessica Barnes, Jamie Dellagatta, Naren Raj Ramakrishna, Charles Dean Stiles, Andrew Li-Jen Kung, Mark W. Kieran, Patrick Yung Chih Wen, Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro-oncology. ,vol. 11, pp. 109- 121 ,(2009) , 10.1215/15228517-2008-060
Karin Nord, Joakim Nilsson, Björn Nilsson, Mathias Uhlén, Per-Åke Nygren, A combinatorial library of an α-helical bacterial receptor domain "Protein Engineering, Design and Selection". ,vol. 8, pp. 601- 608 ,(1995) , 10.1093/PROTEIN/8.6.601
Ann-Charlott Steffen, Maria Wikman, Vladimir Tolmachev, Gregory P. Adams, Fredrik Y. Nilsson, Stefan Ståhl, Jörgen Carlsson, In Vitro Characterization of a Bivalent Anti-HER-2 Affibody with Potential for Radionuclide-Based Diagnostics Cancer Biotherapy and Radiopharmaceuticals. ,vol. 20, pp. 239- 248 ,(2005) , 10.1089/CBR.2005.20.239
P. M. Guy, J. V. Platko, L. C. Cantley, R. A. Cerione, K. L. Carraway, INSECT CELL-EXPRESSED P180ERBB3 POSSESSES AN IMPAIRED TYROSINE KINASE ACTIVITY Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 8132- 8136 ,(1994) , 10.1073/PNAS.91.17.8132