Squalamine: an aminosterol antibiotic from the shark.
作者： K. S. Moore , S. Wehrli , H. Roder , M. Rogers , J. N. Forrest
关键词:
摘要: In recent years, a variety of low molecular weight antibiotics have been isolated from diverse animal species. These agents, which include peptides, lipids, and alkaloids, exhibit antibiotic activity against environmental microbes are thought to play role in innate immunity. We report here the discovery broad-spectrum steroidal tissues dogfish shark Squalus acanthias. This water-soluble antibiotic, we named squalamine, exhibits potent bactericidal both Gram-negative Gram-positive bacteria. addition, squalamine is fungicidal induces osmotic lysis protozoa. The chemical structure 3 beta-N-1-(N-[3-(4-aminobutyl)]- 1,3-diaminopropane)-7 alpha,24 zeta-dihydroxy-5 alpha-cholestane 24-sulfate has determined by fast atom bombardment mass spectroscopy NMR. Squalamine cationic steroid characterized condensation an anionic bile salt intermediate with spermidine. implicates as potential host-defense agent vertebrates provides insights into design family antibiotics.
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