Multiplication of Influenza Virus in the Ehrlich Ascites Carcinoma

摘要: When 40 million tumor cells were injected intraperitoneally into susceptible mice, a uniformly fatal outcome ensued in 14 days. The progress of the was accompanied by an increase number cells, which reached peak 16 × 108 on 11th day, and maximal volume 14th day 19 ml. cells/cu mm 25 104 5th declined thereafter. mitotic index highest 1st at 6.2 per cent. concentration nontumor approached 15 cent first 2 days, dropped to 6 cent, stayed this level until when it returned pH fluid remained close 7.0, but just before animals died rose 7.5. alpha-inhibitor increased moderately as developed, reaching 9th day. Concomitant with multiplication virus there marked destroyed rise tumor. Low levels found lungs brains normal well tumor-bearing mice survived infection. Death 2–5 days after injection virus. cause death not investigated, may be related toxicity observed connection high concentrations influenza Alpha-inhibitor, although present tumors, detectable virus-infected tumors.