Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.

摘要: The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed not readily applicable settings where laboratory resources limited. As a result, existing studies on have used variety non-standardised general definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met Kampala, Uganda, November, 2006. At meeting, paradoxical IRIS, ART-associated tuberculosis, unmasking were derived, which can be high-income settings. It is envisaged that these could by clinicians researchers to promote standardisation comparability data.