Coexisting Prolactinoma and Primary Aldosteronism: Is There a Pathophysiological Link?
作者： Tracy Ann Williams , Anna S. Dietz , Marily Theodoropoulou , Anna Riester , Evelyn Fischer
DOI: 10.1210/JC.2015-2422
关键词:
摘要: Context: Coexisting prolactinoma-primary aldosteronism (PA) is infrequently reported. Objective: The objective of the study was to identify patients with prolactinoma-PA and test hypothesis that elevated prolactin (PRL) concentrations play a role in PA pathogenesis. Setting Design: Hyperprolactinemia/prolactinoma diagnosed from two referral centers (Munich, Germany, Turin, Italy) essential hypertensive (EH) one center (Turin). PRL receptor (PRLR) gene expression determined by microarrays on aldosterone-producing adenomas normal adrenals validated real-time PCR. H295R adrenal cells were incubated 100 nM PRL, levels PCR aldosterone production quantified. Results: Seven identified: four 584 three 442 Munich Turin cohorts, respectively. A disproportionate number presented macroprolactinomas (five seven). T...
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