The Human Antibody Response to Streptococcal C5a Peptidase

摘要: An ELISA was developed to measure antibody, both IgG and IgA, against the streptococcal C5a peptidase (SCP), in human sera saliva. Generally, saliva from young, uninfected children lacked antibody SCP. In contrast, most specimens healthy adults had measurable levels of anti-SCP SCP-specific secretory IgA (anti-SCP sIgA). Paired acute convalescent patients with pharyngitis possessed significantly higher than did individuals. Sera containing high concentrations immunoglobulin were capable neutralizing SCP activity. A survey also showed that latter less likely have sIgA their Detection this greater 90% obtained who recently experienced demonstrated can produce a response. This is thought be first report response humans somatic antigen Streptococcus pyogenes.