Significantly enhanced bioavailability of niclosamide through submicron lipid emulsions with or without PEG-lipid: a comparative study
作者： Xingwang Zhang , Yong Zhang , Tianpeng Zhang , Jianping Zhang , Baojian Wu
DOI: 10.3109/02652048.2015.1057251
关键词:
摘要: AbstractNiclosamide (NL) has demonstrated its great potential in fighting against leukaemia recently. However, either oral or systemic delivery of NL is challenged by insoluble nature. Here, we developed two different NL-loaded submicron lipid emulsions (NL-SLEs) and compared their suitability bioavailability enhancement. Conventional PEGylated NL-SLEs (NL-CSLEs NL-PSLEs) were prepared melt dispersion/high pressure homogenisation technique. They about 307.8 162.2 nm particle size, respectively, both them possessed satisfactory stability drug load (>9.0%). After administration, significantly enhanced was achieved through NL-CSLEs NL-PSLEs (441.11 463.55% relative to the reference). Apart from global exhibited similar attributes release, lipolysis, mucin binding, etc. Taken together, SLEs with without PEG-lipid have shown be promising for NL. could reduce pa...
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