A Reappraisal of Immunoglobulin Variable Gene Primers and Its Impact on Assessing Clonal Relationships Between PB B Cells and BM Plasma Cells in AL Amyloidosis
作者： Nagaaki Katoh , Tanya L. Poshusta , Michelle K. Manske , Angela Dispenzieri , Morie A. Gertz
DOI: 10.1007/S10875-011-9582-Y
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摘要: Monoclonal tumor plasma cells as well non-terminally differentiated B having a clonal relationship to the have been detected in peripheral blood (PB) of some multiple myeloma (MM) patients but rarely light chain (primary systemic) amyloidosis (AL) patients. Previously, our group found these clonotypic three AL Here, we report detailed analysis larger cohort validate prior findings and investigate effect this cell population on clinical outcome. Fourteen were selected from prospective trial, between immunoglobulin variable gene (VL) representation PB bone marrow (BM) was investigated. A not detected, present study provides important insights into disparity with earlier data, including history methodological analysis.
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