Propofol-Induced Vasodilation in Human Internal Mammary Artery: Role of Potassium Channels.

摘要: Objectives The aim of this study was to investigate the vascular effects and mechanisms propofol in human internal mammary artery (IMA). Design In vitro experimental study. Setting conducted in the research laboratory a pharmacology department. Participants IMA segments were obtained from 52 patients undergoing coronary bypass surgery. Interventions rings suspended isolated organ baths, changes tension isometrically recorded. antagonistic effect (1 μM, 10 100 μM) on contractions induced by potassium chloride (45 mM), phenylephrine μM), 5-hydroxytryptamine (30 calcium (10 μM-10 mM) investigated. relaxations also tested presence nitric oxide synthase inhibitor, nitro-L-arginine methyl ester (100 mM); cyclooxygenase indomethacin ion channel inhibitors, tetraethylammonium iberiotoxin (20 nM), glibenclamide µM), 4-aminopyridine barium µM). Measurements Main Results Propofol caused significant concentration-dependent vasorelaxation, which endothelium independent. It inhibited chloride, phenylephrine, 5-hydroxytryptamine, (p Conclusion This clearly reveals that relaxes IMA, propofol-induced vasodilation may be related large conductance ion–activated activation. use surgery can valuable via its favorable vasodilator overcome perioperative vasospasm IMA.