The clinical utility of serum anti-Müllerian hormone in the follow-up of ovarian adult-type granulosa cell tumors--A comparative study with inhibin B.

摘要: Ovarian adult-type granulosa cell tumors (AGCTs) require prolonged follow-up, but evidence regarding the optimal follow-up marker is lacking. The objective of our study was to validate clinical usefulness serum anti-Mullerian hormone (AMH) and current inhibin B as single combined markers AGCTs. We conducted a longitudinal, partially prospective cohort 123 premenopausal postmenopausal AGCT patients with median time 10.5 years (range 0.3-50.0 years). Serum AMH levels were measured from 560 pretreatment samples by using immunoenzymometric assays. found that significantly elevated in primary or recurrent both positively correlated tumor size (p < 0.05). performed similarly receiving operator characteristic analyses; area under curve (AUC) values 0.92 [95% confidence interval (CI) 0.88-0.95] for AMH, 0.94 (95% CI 0.90-0.96) B. highly sensitive (92%) specific (81%) detecting macroscopic AGCT. However, AUC comparison analyses, combination superior alone. In conclusion, AGCT, either can be monitored during follow-up. combining patient improves detection disease.