High prevalence of genotypic and phenotypic HIV-1 drug-resistant strains among patients receiving antiretroviral therapy in Abidjan, Côte d'Ivoire.
作者： Christiane Adjé , Rachanee Cheingsong , Thierry H. Roels , Chantal Maurice , Gaston Djomand
DOI: 10.1097/00126334-200104150-00018
关键词:
摘要: To describe prevalence of antiretroviral (ARV) drug-resistant HIV-1 strains among patients with a history earlier treatment ARV drugs in Abidjan, Cote d'Ivoire, we determined mutations that confer drug resistance by sequencing the viral reverse-transcriptase and protease genes derived from plasma RNA 68 individuals consecutively enrolled Joint United Nations Program on AIDS Drug Access Initiative (UNAIDS-DAI) Abidjan between August 1998 April 1999. Phenotypic was assessed using recombinant virus assay. Primary associated to at least one inhibitors or were detected 39 (57.4%) patients. The was: 29 (42.6%) zidovudine, 10 (14.7%) lamivudine, (1.5%) didanosine, K103N mutation (associated delavirdine, nevirapine, efavirenz), Y181C delavirdine nevirapine), two both indinavir (M46I/L V82A) saquinavir (G48V L90M), each ritonavir (V82A) nelfinavir (D30N). nucleoside reverse transcriptase inhibitor (RTI) seen 25 (39.7%) patients, nonnucleoside RTIs 5 (8%) 4 (6%) high observed this study may limit future effectiveness programs d'Ivoire.
sci-hub.se 参考文章(16)
Steven G. Deeks, Frederick M. Hecht, Melinda Swanson, Tarek Elbeik, Richard Loftus, P. T. Cohen, Robert M. Grant, HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy. AIDS. ,vol. 13, ,(1999) , 10.1097/00002030-199904160-00001
SARAH PALMER, ANNETTE ALAEUS, JAN Albert, SUSAN COX, None, Drug susceptibility of subtypes A,B,C,D, and E human immunodeficiency virus type 1 primary isolates. AIDS Research and Human Retroviruses. ,vol. 14, pp. 157- 162 ,(1998) , 10.1089/AID.1998.14.157
Gerd Fätkenheuer, Albert Theisen, Jürgen Rockstroh, Tanja Grabow, Christian Wicke, Katja Becker, Ulrike Wieland, Herbert Pfister, Marcel Reiser, Petra Hegener, Caspar Franzen, Achim Schwenk, Bernd Salzberger, Virological treatment failure of protease inhibitor therapy in an unselected cohort of HIV-infected patients. AIDS. ,vol. 11, pp. 1402- 1403 ,(1997) , 10.1097/00002030-199714000-00001
John N. Nkengasong, Chantal Maurice, Stéphania Koblavi, Mireille Kalou, Daniel Yavo, Matheiu Maran, Celestin Bile, Kabran Nguessan, Justine Kouadio, Séka Bony, Stefan Z. Wiktor, Alan E. Greenberg, Evaluation of HIV serial and parallel serologic testing algorithms in Abidjan, Côte d'Ivoire. AIDS. ,vol. 13, pp. 109- 117 ,(1999) , 10.1097/00002030-199901140-00015
S Yerly, L Kaiser, E Race, J-P Bru, F Clavel, L Perrin, Transmission of antiretroviral-drug-resistant HIV-1 variants The Lancet. ,vol. 354, pp. 729- 733 ,(1999) , 10.1016/S0140-6736(98)12262-6
Laurence Vergne, Martine Peeters, Eitel Mpoudi-Ngole, Anke Bourgeois, Florian Liegeois, Coumba Toure-Kane, Souleymane Mboup, Claire Mulanga-Kabeya, Eric Saman, Jacques Jourdan, Jacques Reynes, Eric Delaporte, Genetic Diversity of Protease and Reverse Transcriptase Sequences in Non-Subtype-B Human Immunodeficiency Virus Type 1 Strains: Evidence of Many Minor Drug Resistance Mutations in Treatment-Naive Patients Journal of Clinical Microbiology. ,vol. 38, pp. 3919- 3925 ,(2000) , 10.1128/JCM.38.11.3919-3925.2000
Susan J Little, Eric S Daar, TD Richard, Philip H Keiser, Elizabeth Connick, Jeannette M Whitcomb, Nicholas S Hellmann, Christos J Petropoulos, Lorraine Sutton, Jacqui A Pitt, Eric S Rosenberg, Richard A Koup, Bruce D Walker, Douglas D Richman, Reduced Antiretroviral Drug Susceptibility Among Patients With Primary HIV Infection JAMA. ,vol. 282, pp. 1142- 1149 ,(1999) , 10.1001/JAMA.282.12.1142
John N Nkengasong, Chantal Maurice, Stéphania Koblavi, Mireille Kalou, Celestin Bile, Daniel Yavo, Emmanuel Boateng, Stefan Z Wiktor, Alan E Greenberg, Field Evaluation of a Combination of Monospecific Enzyme-Linked Immunosorbent Assays for Type-Specific Diagnosis of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 Infections in HIV-Seropositive Persons in Abidjan, Ivory Coast Journal of Clinical Microbiology. ,vol. 36, pp. 123- 127 ,(1998) , 10.1128/JCM.36.1.123-127.1998
Kurt Hertogs, Marie-Pierre de Béthune, Veronica Miller, Tania Ivens, Patricia Schel, Anja Van Cauwenberge, Christel Van den Eynde, Veerle van Gerwen, Hilde Azijn, Margriet van Houtte, Frank Peeters, Schlomo Staszewski, Marcus Conant, Stuart Bloor, Sharon Kemp, Brendan Larder, Rudi Pauwels, A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs Antimicrobial Agents and Chemotherapy. ,vol. 42, pp. 269- 276 ,(1998) , 10.1128/AAC.42.2.269
Martin S. Hirsch, Brian Conway, Richard T. D'Aquila, Victoria A. Johnson, Françoise Brun-Vézinet, Bonaventura Clotet, Lisa M. Demeter, Scott M. Hammer, Donna M. Jacobsen, Daniel R. Kuritzkes, Clive Loveday, John W. Mellors, Stefano Vella, Douglas D. Richman, for the International AIDS Society–USA Panel, Antiretroviral drug resistance testing in adults with HIV infection: Implications for clinical management JAMA. ,vol. 279, pp. 1984- 1991 ,(1998) , 10.1001/JAMA.279.24.1984