5'-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus.
作者： S P Kwak , P D Patel , R C Thompson , H Akil , S J Watson
DOI: 10.1210/ENDO.133.5.8404687
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摘要: The mineralocorticoid receptor (MR) cDNA we previously isolated from the rat hippocampus differs clone kidney at 5'-untranslated (5'UT) region. (alpha MR mRNA) and hippocampal (beta possess unique 5'UT sequences of 220 300 nucleotides, respectively, but share an invariant peptide-coding domain appear to encode identical protein. two mRNA variants may represent tissue-specific forms or be coexpressed in along with other variants. Here, report that three subtypes were found hippocampus; their relative abundance was as follows: alpha = beta >> gamma. differentially distributed within subfields, form being highly enriched CA2, dentate, fasciculum cinereum, indusium griseum, whereas gamma evenly through CA1-4. Adrenalectomy selectively increased content, ...
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