Templated biological synthesis of polymers of abiological monomers
作者： Srinivas Kothakota , Michael J. Dougherty , Maurille J. Fournier , Thomas L. Mason , Eiichiro Yoshikawa
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摘要: A general method for the in vivo incorporation of amino acid analogues into artificial proteins is described. The involves construction an gene encoding sequence interest (with corresponding natural encoded place analogue), transformation a bacterial host strain that cannot synthesize acid, and induction protein synthesis culture enriched analogue. Results are described selenomethionine, p-fluorophenylalanine, trifluoroleucine 3-thienylalanine.
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