Recent advances in selective α1-adrenoreceptor antagonists as antihypertensive agents
作者： Kishor S. Jain , Jitender B. Bariwal , Muthu K. Kathiravan , Manisha S. Phoujdar , Rajkumari S. Sahne
DOI: 10.1016/J.BMC.2008.02.091
关键词:
摘要: Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients. Selective α1-adrenoreceptor antagonists though have many advantages and uses in the management of arterial hypertension, their lack of specificity at the level of α1-adr subtypes leads to multiple side effects. Existence of multiple α1-adr subtypes holds great promise for the discovery and development of more specific and selective drug molecules, targeting only one α1-adr subtype at a time and thus relative …
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