摘要: Numbers and sizes of fibers from the lungs 10 patients who had an amphibole asbestos-induced malignant pleural mesothelioma were analyzed. Amosite was found in crocidolite 9; average ratio amosite to approximately 14:1. In 8 not long-time asbestos insulators , mean number 2.3 X 10(6) fibers/g dry lung, fibers, 0.2 10(6)/g; these values represent 250-fold increase over those general population. Crocidolite significantly narrower than (mean width, 0.13 versus 0.23 mu), shorter length, 4.0 5.8 a higher aspect (length width) (48 34). Aspect ratios increased with increasing fiber length decreasing but highest for thin at about 13 mu or 15-17 length. Comparison data other asbestos-exposed populations indicates that can be induced by relatively small numbers also is effective mesothelial carcinogen humans. epidemiologic experimental predictions carcinogenic size ranges induction implies either range much broader has been claimed (in particular, considerably 0.05 produce mesothelioma), or, alternately, extraordinarily absolute certain induce tumors
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