A monoclonal antibody to α4 integrin suppresses and reverses active experimental allergic encephalomyelitis
作者： S Kent
DOI: 10.1016/0165-5728(94)00165-K
关键词:
摘要: Abstract In experimental allergic encephalomyelitis (EAE), circulating leukocytes enter the central nervous system (CNS) producing inflammation, myelin damage and paralysis. Prevention of leukocyte infiltration by an antibody against α4 integrin suppressed clinical pathological features EAE in guinea pig. Rapid clearance from CNS reversal findings were observed when anti-α4 treatment was administered during active disease. Clinical improvement accompanied a marked decrease abnormal findings, including demyelination. Therefore is effective may be similarly useful autoimmune diseases such as multiple sclerosis.
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