Diastereoselective building up polycyclic tetrahydrofurans via tandem annulation of 1,n-enynes with aliphatic acids
作者： Leiyang Lv , Shenglin Lu , Yuanjin Chen , Zhiping Li
DOI: 10.1039/C7QO00527J
关键词:
摘要: A silver-catalyzed tandem annulation of aniline-linked 1,7-enynes with aliphatic acids has been reported. This synergistic annulations allow the straightforward and efficient building up various highly diastereoselective polycyclic tetrahydrofurans. Primary secondary undergo decarboxylation/cascade radical addition/α-C(sp3)–H cleavage/cycloalkylation/O-trapping to generate oxygenous [6.6.6.5] fused products. While tertiary radcial addition/β-C(sp3)–H cleavage/O-trapping give [6.6.6.6]
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