摘要: Everyday activities damage bone, and this is normally repaired in a continuous remodelling process. When an imbalance process occurs, bones may become more susceptible to fracture. This paper concerned with derivation of: (a) the general rule for bone interaction anisotropic (b) associated thermodynamic restrictions. The procedure of Coleman Noll, utilizing Clausius–Duhem inequality used provided as basis consistent formulation involving chemical reaction mass transfer between two constituents presence microcracks. It hoped that work provides rational practical use such theoretical results.