Blood culture status and mortality among patients with suspected community-acquired bacteremia: a population-based cohort study

摘要: Comparison of mortality among patients with positive and negative blood cultures may indicate the contribution bacteremia to mortality. This study (1) compared community-acquired (2) determined effects type comorbidity level on cultures. cohort included 29,273 adults performed within first 2 days following hospital admission an internal medical ward in northern Denmark during 1995-2006. We computed product limit estimates used Cox regression compute adjusted rate ratios (MRRs) 0-2, 3-7, 8-30, 31-180 for culture-negative patients. Mortality 2,648 bacteremic 26,625 was 4.8% vs. 2.0% 0-2 after admission, 3.7% 2.7% 3-7 5.6% 5.1% 8-30 9.7% 8.7% corresponding MRRs 1.9 (95% confidence interval (CI): 1.6-2.2), 1.1 CI: 0.9-1.5), 0.9 0.8-1.1), 1.0 respectively. higher Gram-positive (adjusted 0-2-day MRR 1.9, 95% 1.6-2.2) polymicrobial 3.5, 2.2-5.5) than Gram-negative 1.5, CI 1.2-2.0). After days, had same risk dying as 0.8, 0.5-1.1). Only increased 1.3, 0.8-2.1) The association between culture status did not differ substantially by comorbidity. Community-acquired associated week admission. Higher emphasizes prognostic importance these infections.