Redox Regulation of Multidrug Resistance in Cancer Chemotherapy: Molecular Mechanisms and Therapeutic Opportunities
作者： Macus Tien Kuo
关键词:
摘要: The development of multidrug resistance to cancer chemotherapy is a major obstacle the effective treatment human malignancies. It has been established that membrane proteins, notably (MDR), protein (MRP), and breast (BCRP) ATP binding cassette (ABC) transporter family encoding efflux pumps, play important roles in resistance. Overexpression these transporters observed frequently many types malignancies correlated with poor responses chemotherapeutic agents. Evidence accumulated showing redox signals are activated response drug treatments affect expression activity by multiple mechanisms, including (a) conformational changes transporters, (b) regulation biosynthesis cofactors required for transporter's function, (c) at transcriptional, posttranscriptional, epigenetic levels, (d) amplification copy number genes transporters. This review describes various specific factors their relevant signaling pathways involved regulation. Finally, maintenance evolution stem cells implications intrinsic acquired discussed. Antioxid. Redox Signal. 11, 99–133.
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