Transmission intensity and human immune responses to lymphatic filariasis.

摘要: Our understanding of how the host immune response influences risk developing disease has changed dramatically over past decade. Previously, spectrum associated with lymphatic filariasis was largely attributed to nature response. Now, we appreciate that duration and intensity infection possibly direct influence parasite-derived molecules also determine disease. Individuals chronically infected generally have an impaired lymphocyte proliferation filarial antigens favour Th2-type cytokine responses. This ability down-modulate may help protect from Defects in antigen-presenting cell (APC) function appear participate this acquired hyporesponsiveness, although mechanisms as occurs are poorly understood. Here, present evidence repeated exposure infective stage larvae their secreted products stimulate basophils mast cells related impair APC function.